Welcome to the Proteomics Lab
We are a Proteomics and Bio-analytical Mass Spectrometry lab in the Chemistry and Biochemistry Department at the University of Texas at Arlington in Arlington, Texas.
Our laboratory focuses on mass spectrometry-based method development in the following specific areas of proteomics research:
- Global and targeted discovery of protein-protein/protein-ligand interactions by antibody/affinity-based enrichment methods in combination with novel mass spectrometry-supportive chemical cross-linking approaches.
- Identification and quantitative characterization of protein posttranslational modifications (PTMs) by mass spectrometry- supportive chemical probes.
- Elucidation of protein structures by mass spectrometry.
- Quantitative proteomics studies for the discovery and validation of cellular protein targets (bio-signatures or bio-markers)
The focused biological application of our research is to understand the role of lipid rafts and Toll-like Receptors (TLRs) in inflammatory signaling pathways. We focus on studying several environmental diseases impacted by innate immunity, such as atherosclerosis, sepsis, cancer, etc. by mass spectrometry-based novel proteomics tools. In addition, the approaches we develop can be generally applied to any biological systems; hence we also welcome researchers to initiate collaborative research efforts with us.